GEMMs mimicking the conditional loss of Crebbp share remarkable similarities with the Kmt2d-KO model, including: a) the increase in GC B cells with partially overlapping transcriptional changes; b) a more pronounced GC phenotype in Cd19-Cre background compared to Cγ1-Cre mice; c) the inability to drive full-blown tumor formation on their own, but a strong synergistic activity with BCL2 deregulation, leading to acceleration of lymphoma onset and increased penetrance of FL (46, 110). The gene discussed is BCL2; the disease is lymphoma.