In line with this hypothesis, transplantation of VavP-Bcl2;H1c-/+H1e-/+ lymphoma cells into secondary and tertiary recipient mice yielded 100% engraftment, which was not observed with the VavP-Bcl2 only tumors, consistent with the fact that H1 mutant DLBCL are highly aggressive (120). Here, BCL2 is linked to diffuse large B-cell lymphoma.