Despite this limitation, young VavP-Bcl2 mice display spontaneous, antigen independent GC hyperplasia, and develop over time B-cell lymphomas that faithfully recapitulate the GC origin of the human FL, along with other critical aspects of its pathobiology such as the follicular pattern, the expression of peanut-agglutinin (PNA) and BCL6 in the absence of post-GC markers, and the presence of clonally rearranged IGHV genes that are somatically mutated (98). This evidence concerns the gene BCL6 and B-cell non-Hodgkin lymphoma.