In both models, expression of the mutant Ezh2 knock-in allele did not lead to lymphomas; however, accelerated lymphomagenesis was observed when mice were crossed with VavP-Bcl2 transgenics or upon adoptive transfer of VavP-Bcl2 BM cells transduced with Ezh2Y641F vectors (115, 117, 118). This evidence concerns the gene BCL2 and lymphoma.