Additionally, CREBBP directly acetylates several proteins that are relevant to B cell lymphoma biology, including the TP53 tumor suppressor, which requires acetylation for its activity, and the BCL6 protein, which instead is functionally impaired by acetylation due to the lost interaction with co-repressor complexes (95, 113). The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.