Besides documenting the oncogenic role of EZH2 mutations, the value of the Ezh2;Cγ1-Cre GEMMs is twofold: first, they revealed an additional function of Ezh2 in shaping the tumor microenvironment, providing an opportunity to study syngeneic immune responses (see following section); second, they proved to be a valuable tool for the preclinical testing of novel therapeutic approaches, as tumors developing in these mice replicate the human phenotype in several aspects related to the tumor microenvironment. The gene discussed is EZH2; the disease is neoplasm.