BCL6 and diffuse large B-cell lymphoma: A successful example of the latter approach is represented by the Iμ-HABCL6 mouse model, where a BCL6 cDNA cassette was targeted downstream the endogenous immunoglobulin Iμ promoter to generate a chimeric transcriptional unit reproducing the outcome of a common BCL6 chromosomal translocation variant found in DLBCL (37) (further discussed in the DLBCL section).