H1-0 and diffuse large B-cell lymphoma: FL and DLBCL also feature recurrent somatic mutations in histone genes, with the linker Histone H1 family being most commonly affected (up to 44% of FL and 26% of GCB-DLBCL cases), and the HIST1H1C and HIST1H1E family members accounting for the majority of mutations (94, 120).