Accordingly, enforced expression of NIK and BCL6 in the GC, as obtained by conditional mutagenesis in the IμHABcl6;NikstopFL;Cγ1-Cre mouse model, caused GC hyperplasia with blockade of terminal differentiation and development of IRF4-positive DLBCL (168). Here, BCL6 is linked to diffuse large B-cell lymphoma.