Iμ.HA.BCL6 mice show GC hyperplasia with increased DZ : LZ ratio also in the absence of antigenic stimulation, and develop over time clonal lymphomas that recapitulate key aspects of DLBCL, most notably the evidence of AID-dependent aberrant somatic hypermutation and the presence of stochastic Myc-IgH translocations (37, 79). This evidence concerns the gene AICDA and diffuse large B-cell lymphoma.