As a whole, we can affirm that CHF CMV+ patients compared with CMV- patients present an expression profile in CD4+ T-lymphocytes Th1 type, more activated and with a highly differentiated and highly reactive CD4+CD28null T population, that is possibly the result of the own fight against CMV infection and the environment, even more pro-inflammatory than in CMV- patients. The gene discussed is CD4; the disease is congestive heart failure.