NFE2L2 and Chronic colitis: The animals were randomly allocated to six groups (n=8 per group): (i) normal control group (sterile water), (ii) chronic colitis group (DSS), (iii) mesalazine group (mesalazine + DSS), (iv) treatment group (ME + DSS), (v) Nrf2 inhibitor group (DSS + ML385 + ME), and (vi) ME group (sterile water + ME).