Wu et al. (2014) showed that miR-223 was significantly decreased after infection with DENV-2 in human endothelial Eahy926 cells and that this overexpression inhibited the replication of DENV-2. This is because miR-223 downregulates the expression of STMN1 through the STMN1 gene, a microtubule instability protein targeting the 3'-UTR of viral RNA, thus inhibiting virus replication (Wu et al., 2014). The gene discussed is STMN1; the disease is infection.