Above, we referred to enhanced miR-150 expression is associated with depressed SOCS1 expression involved in DHF (Chen et al., 2014) and we have discussed how differential expression of miRNAs in blood samples in clinical patients can be used to distinguish between the severity of dengue patients (Tambyah et al., 2016), and dysregulated miRNAs in serum samples may mediate inflammatory responses and cell proliferation (Ouyang et al., 2016), which expands our understanding of the pathogenesis of miRNAs and DHF in vivo studies. This evidence concerns the gene SOCS1 and Dengue hemorrhagic fever.