It was also reported (40) that glucocorticoid elevation leads to decreased expression of brain-derived neurotrophic factor (BDNF) in depressive mouse hippocampus and in PC12 cells, while OCN exerted a protective effect for depression and anxiety by increasing BDNF expression through activation of cAMP/PKA signaling in mice (21). The gene discussed is BDNF; the disease is depressive disorder.