More than 10 different autosomal-recessive pathogenic mutations in SDHA have been reported to cause LS, Leigh’s-like, and other related mitochondrial disorders, while mutations in SDHAF1 (a complex II assembly factor), SDHB, and SDHD have also been reported to cause LS or LS-like symptoms (Supplementary Table 1). Here, SDHA is linked to Leigh syndrome.