In a clinical report of a 15-month-old female LS patient of European descent, two homoplasmic mutations involving m.14792C > G and m.14459G > A was reported that resulted in p.His16Asp change in MT-CYB and p.Ala72Val substitution in the ND6 subunit, respectively (Ronchi et al., 2011). The gene discussed is MT-ND6; the disease is Leigh syndrome.