In situations where the activity of GPs facilitates the initiation and maintenance of AF, GP ablation could result in more beneficial than detrimental effects (Krul et al., 2014); however, there are still a several aspects related to GP ablation that deserve further investigation, including whether reinnervation occurs in the long-term after GP ablation and whether this could contribute to AF recurrence. The gene discussed is NBEAL2; the disease is atrial fibrillation.