Extracellular signal-related kinase 5 (ERK5) is a mitogen-activated protein kinase (MAPK) that elicits the production of multiple inflammatory cytokines and enhances VEGF production in many inflammatory disorders and in diabetes (Kondoh et al., 2006; Wang and Tournier, 2006; Hayashi et al., 2004; Dorado et al., 2008; Chen et al., 2019). This evidence concerns the gene VEGFA and diabetes mellitus.