AKT1 and psoriasis: Studies have reported overactivity of mTORC1 and its downstream molecule ribosomal protein S6 kinase 1 (S6K1) in the skin lesions of patients with psoriasis (Buerger et al., 2017; Rabanal-Ruiz and Korolchuk, 2018), and the highly active Akt/mTORC1/S6K1 pathway can lead to the abnormal differentiation of keratinocytes, which is generally recognized as an important pathological feature of psoriasis (Akinduro et al., 2016; Balato et al., 2017; Cai et al., 2019).