Our study showed that 0.125 g/ml and 0.25 g/ml of FZHFZY could down-regulate the ratio of p-Akt/Akt, p-mTOR/mTOR, raptor, p-S6K1/S6K1 and pS6/S6 in the skin lesions of mice with IMQ-induced psoriasis, which suggests that FZHFZY regulates epidermal differentiation via inhibition of the Akt/mTORC1/S6K1 pathway. This evidence concerns the gene RPS6KB1 and psoriasis.