In the current study, the new findings were found as follows: (1) Early aged hypertension activated neural EndoG and AIF-related Caspase-independent, Fas-mediated Caspase-dependent, and mitochondrial-mediated Caspase-dependent apoptotic pathways as well as inhibited Bcl-2 family-related and Sirt1/PI3K/AKT related pro-survival pathways in the cerebral cortex. The gene discussed is SIRT1; the disease is Hypertension.