As reported in this study, EGCG treatment prevented overactive EndoG and AIF-related Caspase-independent apoptotic pathway in early aged hypertension, as evidenced by reductions in the ratios of cytosolic EndoG to mitochondrial EndoG as well as cytosolic AIF to mitochondrial AIF proteins in the early aged hypertensive cerebral cortex after EGCG treatment, suggesting that EGCG treatment could alleviate the translocation of EndoG and AIF from neural mitochondria to neural cytosol. Here, AIFM1 is linked to hypertensive disorder.