We hypothesized that cerebral cortex apoptosis on the early aged hypertension is enhanced as well as that EGCG might prevent neural EndoG and AIF-related Caspase-independent apoptotic pathway, Fas-mediated Caspase-dependent apoptotic pathway, and mitochondrial-mediated Caspase-dependent apoptotic pathway, as well as enhance Bcl-2 family-related and Sirt1/PI3K/AKT related pro-survival pathways, in the cerebral cortex under early aged hypertension. Here, SIRT1 is linked to hypertensive disorder.