Our results indicated the new finding that EGCG treatment was able to prevent the early aged hypertension-activated Fas-mediated Caspase-dependent neural apoptotic pathway, as evidenced by the down-regulated levels of FasL, Fas, FADD, Caspase-8, and Caspase-3 in the hypertensive cerebral cortex. Here, CASP8 is linked to hypertensive disorder.