Although there was no previous evidence that mentioned the effects of EGCG on Bcl-2 family-related pro-survival pathway in the early aged hypertensive brain, previous studies showed that EGCG enhanced Bcl-2 protein levels in the cerebral ischemia brain (Nan et al., 2018) and in radiation-induced hippocampal apoptosis (El-Missiry et al., 2018). Here, BCL2 is linked to Cerebral ischemia.