To evaluate the effects of EGCG on neural pro-survival pathway under early aged hypertension, the levels of Sirt1, PI3K, p-PI3K, AKT, and p-AKT in the cerebral cortex tissue from WKY, SHR, and SHR-EGCG groups were determined by Western blotting. This evidence concerns the gene SIRT1 and hypertensive disorder.