SNCA and synucleinopathy: PD is the most frequent type of synucleinopathy which is pathologically characterized by proteinaceous cytoplasmic inclusions, primarily consisting of alpha-synuclein and ubiquitin (Tagliafierro and Chiba-Falek, 2016; Balestrino and Schapira, 2020; Toffoli et al., 2020).