TTC21B and epilepsy: To identify risk genes whose genetically regulated expression change are associated with epilepsy, we further conducted a TWAS by integrating genome-wide summary statistics of epilepsy (from meta-analysis) and SNP-gene expression weights from the PsychENCODE (N = 1,371).9 Three genes (TTC21B, RP11-375N15.2, and TNKS) showed transcriptome-wide significant (TWS) associations (Bonferroni corrected p < 0.05) with epilepsy (Figure 4), indicating that risk variants may confer epilepsy risk through regulating the expression of these genes.