Although the genome-wide association signal (Figure 2A) and previous studies (Claes et al., 2001, 2009; Meng et al., 2013; Parihar and Ganesh, 2013; International League Against Epilepsy Consortium on Complex Epilepsies, 2014; Haigh et al., 2021) have clearly showed that SCN1A represents the most possible causal gene for this risk locus, our TWAS suggested that TTC21B may also have a potential role in epilepsy (Figure 4). The gene discussed is SCN1A; the disease is epilepsy.