SCN1A and epilepsy: Of note, the most significant variant (lead SNP rs11890028) on 2q24.3 resides in the intron 7 of SCN1A, a well-characterized risk gene for epilepsy (Claes et al., 2001; Parihar and Ganesh, 2013; International League Against Epilepsy Consortium on Complex Epilepsies, 2014; Figure 2B).