Considering the important role of Wnt/beta-catenin signaling (Bengoa-Vergniory and Kypta, 2015; Arnes and Casas Tinto, 2017; Noelanders and Vleminckx, 2017; Bem et al., 2019) and PTEN (Endersby and Baker, 2008; Zhou and Parada, 2012; Spina Nagy et al., 2021) in the brain, it is possible that TNKS confers risk of epilepsy by regulating Wnt/beta-catenin signaling pathway. The gene discussed is PTEN; the disease is epilepsy.