TNNC1 and cardiomyopathy: TNNC1 encodes slow skeletal and cardiac-type troponin C1, and its mutations play an essential role in the development of cardiomyopathy, in which the TNNC1-A8V mutant evokes diastolic disorder through raising the calcium-ion-binding affinity of the thin filament and altering calcium ion homeostasis and cellular remodeling [92].