HNF4A and cancer: In normal cells, BCL9 expression is almost undetectable,393 but it reigns a set of EMT-regulated Wnt target genes in cancer cells.394 And after knocking out Bcl9 and B9l in mice, no obvious harmful phenotypes were found, indicating that these genes are of little importance for mammals to balance Wnt signaling in normal tissues.394 Based on this, Takada et al. developed the stapled peptide stabilized α helix of BCL9 (SAH-BCL9), which can snatch β-catenin from the endogenous Bcl9/Tcf/β-catenin complex with greater affinity.