EGFR and colorectal carcinoma: EGFR-driven NSCLC was suppressed by the synergistic function of AZ1366 and EGFR inhibitors.348 AZ1366 could erase the insensitivity of CRC cells to irinotecan,349 and it coordinated with EGFR inhibitor to control the growth of Wnt-responsive lung cancers in the murine models.348 RK-287107 was claimed to inhibit Tnks1/2 four or eight times more than G007-LK.