Axin1 mutations were detected widely in HCC.156,157 This mutation could phenocopy various tumors in animal models.158,159 Axin2 can partially compensate for the functional impairment caused by Axin1 mutation.155,158,160 Axin2 dysfunction was associated with a variety of tumors, including endometrial cancer,161 CRC,162–165 lung cancer,166,167 and breast cancer.168–170 In these cancers, Axin2 performed suppressive roles by mainly constraining the level of β-catenin. This evidence concerns the gene AXIN2 and hepatocellular carcinoma.