Inhibition of Axin and Apc complex together promoted tumor genesis and progression by enhancing Wnt/β-catenin signaling.153,154 Controlling Axin polymerization may be a potential therapeutic choice to suppress cancer development.154,155 Mutations of AxinCR were reported to accelerate the tumorigenesis in the following cancers: HCC, colorectal adenomas, ovarian carcinomas, lung carcinomas, and sporadic medulloblastomas. Here, AXIN1 is linked to hepatocellular carcinoma.