APC and Familial prostate cancer: Apc also suppresses other cancers, such as lung, breast, gastric, and prostate cancers, excepting for CRC.140–144 The DNA methylation of Apc promoter is closely associated with various cancers, like lung cancer and prostatic cancer.145,146 The methylation reduces the normal expression of Apc in cancers, resulting in abnormal activation of the Wnt/β-catenin signaling pathway.