ZNRF3 and pancreatic neoplasm: LGK974, targeting on Wnt/β-catenin signaling, alleviated Rnf43 mutation-associated pancreatic cancer cell proliferation, however, which did not affect the non-mutant cancers.124 For CRC, Rspo/Rnf43 dysregulation plays a positive role in development and dominates over Znrf3.125,126 There still needs further researches to explore the relation between Wnt/β-catenin and Znrf3/Rnf43, as well as them in cancers.