For instance, NVP-TNKS656 increased the sensitivity of CRC cells to PI3K/AKT inhibitor in vivo, but the increment effect could be reversed by high FOXO3A.346 And NVP-TNKS656 also inhibited the metastatic and invasive EMT hallmarks of hepatoma carcinoma cells.347 AZ1366 is a novel inhibitor of Tnks to constrain NSCLC growth. This evidence concerns the gene TNKS and colorectal carcinoma.