EGFR and colorectal carcinoma: JW55 also worked well in the murine PDX CRC model with Apc mutation.337 G007-LK is an analog of JW74, and G244-LM is analogous to XAV939.171,336 Compound G007-LK and G244-LM can damage the proliferation, colony formation, and growth of CRC cells via activating Axins to suppress Wnt/β-catenin signaling.338 As an adjuvant, G007-LK can also enhance the sensitivity of glioma stem cells to a chemo drug temozolomide and CRC cells to PI3K/EGFR inhibitors.339,340