For instance, Dvl2 was overexpressed in HCC and reported to link with poor prognosis.367 In comparison to normal adult bronchial/alveolar epithelial and peripheral blood mononuclear cells, Dvl1-3 were found to be exclusively expressed in NSCLC and CLL cells, respectively.368,369 Most drugs targeting Dvls currently are developed to selectively inhibit PDZ-Fzd interaction. Here, DVL1 is linked to non-small cell lung carcinoma.