JW67 and JW74, two compounds as inhibitory molecules of Wnt/β-catenin signaling, can inhibit the growth of CRC by Axin2 accumulation and β-catenin degradation.336 JW74 and JW55 are Tnks inhibitors that bind to the lower part of donor NAD+ cleft, instead of mimicking nicotinamide. Here, AXIN2 is linked to colorectal carcinoma.