Both neuroimaging and cerebrospinal fluid (CSF) biomarker studies indicate a consistent association of APOE ε4 with higher cerebral Aβ deposition in cognitively healthy elderly individuals and across the full clinical continuum of AD, i.e., in patients with subjective memory complaint, prodromal (or mild cognitive impairment (MCI)) and dementia [50–54]. The gene discussed is APOE; the disease is Alzheimer disease.