Production of NO by eNOS has protectiveeffects in many models of cardiovascular diseases (CVD)such as cardiac hypertrophy (9), myocardial infarction(MI) (10) and cardiac ischemia/reperfusion injury (11).The results of studies show that eNOS-NO activatesnuclear factor erythroid-2-related factor 2 (NRF2) andperforms anti-oxidative stress, anti-apoptosis and cardiac-protective effects (12). Here, NOS3 is linked to cardiac hypertrophy.