TP53 and cancer: Interestingly, our findingsdisplayed a positive correlation between hub characteristic and survival rate, despiteCCNB2 lacking a high betweenness in cancer signature genes network.Accumulating evidences suggest that CCNB2 and p53 tumor-suppressor proteins functionantagonistically in regulating aurora-A-mediated centrosome separation and correctingchromosome segregation in the late G2 by provoking the phosphorylation of aurora A (AURKA).AURKA, a serine/threonine kinase, is a vital oncogene in epithelial–mesenchymal transition,cancer stem cell development and distant metastasis (37).