In contrast to relative expression of DNMT1 (fertile: 5.00 ± 1.4 vs.varicocele: 4.97 ± 1.2, P=0.98), the relative expression of both DNMT3A(fertile: 1.87 ± 0.5 vs. varicocele: 4.83 ± 1.2; P=0.02) and DNMT3B(fertile: 0.93 ± 0.26 vs. varicocele: 2.78 ± 0.61, P=0.008) were significantly higher inindividuals with varicocele in comparison with fertile men (Fig .4). This evidence concerns the gene DNMT1 and varicocele.