In line with vimentin [29], an accelerator for tumor growth, invasion, progression, and metastasis, as well as an independent prognosticator for poor prognosis and survival in various epithelial cancer patients [28, 29], the current study demonstrated that only the specific subtype of baseline Vim+ CTECs with multiploid chr8 exhibited a predictive value for patients’ poor prognosis, showing that all patients harboring this subtype of CTECs prior to treatment had new mets at PD (Fig. 5B) and a shortened mPFS (Fig. 5Ca). This evidence concerns the gene VIM and neoplasm.