Aneuploidy is a hallmark of malignancy that drives lethal progression in cancer cells, showing the degree of aneuploidy is proportional to the grade of malignancy of neoplastic cells, the higher the degree of aneuploidy, the higher frequency of KRAS and TP53 mutations, and the higher the malignancy grade, as well as the adverse prognosis [40, 45]. This evidence concerns the gene TP53 and cancer.