Individuals with pro-NT levels above the median value at baseline (high-proNT; median pro-NT in the T1D group = 161.8 pmol/L) showed significantly greater waist circumference (p = 0.03), LDL-cholesterol (p = 0.02), triglycerides (p = 0.01), FBG (p = 0.01), HbA1c (p = 0.04), insulin requirement (p = 0.04), and lower AST/ALT ratio (p = 0.02) at follow-up when compared with patients with basal pro-NT levels below the median value (low-proNT). The gene discussed is INS; the disease is type 1 diabetes mellitus.