Traf2- and Nck-interacting kinase is a regulatory component of the β-catenin transcription factor that modulates EMT during colorectal cancer metastasis (99); and the soluble form of EPHB4 plays a key role in inhibiting platelet-derived growth factor–induced RPE cell attachment, proliferation, and attachment (69). The gene discussed is MAP4K4; the disease is colorectal cancer.