Taken together, targeting some deubiquitinases, such as USP7, USP9X, USP10, USP15, USP25 and USP47, can effectively overcome TKIs resistance in CML, and some deubiquitinases play an important role in maintaining the self-renewal ability of CML stem/progenitor cells. Here, USP15 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.