GBA1 and synucleinopathy: Nevertheless, it is interesting that many genetic risk factors associated with α-synucleinopathies, such as glucocerebrosidase insufficiency as well as aging are likely to have impacts on these lysosomal functions and activities that can result in reduced efficiency in the degradation of αSyn and the aberrant accumulation of αSyn carboxy truncated products [4, 17, 32, 52, 67].