IDE and Alzheimer disease: However, continuous treatment with geniposide for 4 weeks not only significantly reduced the concentration of β-amyloid peptides (Aβ1-40 and Aβ1-42) in the brains of AD mice induced by STZ but also increased the protein levels of β-site APP cleaving enzyme (BACE1) and insulin-degrading enzyme (IDE) and reduced the protein level of ADAM10.