However, ITP mouse showed significantly increased Th1 cells (Fig. 2A), T-bet mRNA expression (Fig. 2B) and IFN-γ level (Fig. 2C) compared with normal mice (P < 0.05), consistent with the role of Th1 cells in the pathogenesis of ITP patients. Here, IFNG is linked to autoimmune thrombocytopenic purpura.