CD8A and neoplasm: In murine models, effector CD8+ T cells expressing HRs α4β1 integrin, the chemokine receptor CXCR3, and E-selectin ligand (ESL), are recruited based on expression of their ligands (VCAM-1, CXCL9/CXCL10/CXCL11, and E selectin (SELE), respectively) in the endothelium of the tumor vasculature [25].