Some of these HRLs are induced by interferon-gamma (IFNγ) in the TME, suggesting a feed-forward loop whereby infiltration by CD8+ T cells is followed by their production of IFNγ, which upregulates expression of the HRLs on tumor vasculature, which in turn enhances infiltration by more effector CD8 T cells [25]. The gene discussed is CD8A; the disease is neoplasm.