Having identified a set of ICH genes whose expression was highly associated with Immunotype Score, we next determined whether distinct subsets of ICH genes were associated with intratumoral density of CD45+ cells along with immune cell subsets including CD8+ T cells, CD4+ T cells, CD20+ B cells, CD138+ plasma cells, CD56+ natural killer-NK cells, and CD163+ Type 2 macrophages/monocytes from TMA cores analyzed by IHC on the same tumor specimens as the ICH gene assay. The gene discussed is SDC1; the disease is neoplasm.