FANCD2 and neoplasm: Indeed, when we divided tumor samples based on their ALDH2 expression levels and performed differential gene expression analysis, the FA pathway was one of the highly upregulated pathways among these two groups (Fig. 4e, Supplementary Fig. 8a, b), and the FA pathway components BRIP1, FANCD2 and FANCI were consistently upregulated across different tumor types (Fig. 4f, Supplementary Fig. 8c, d) and independently of tumor stage (Supplementary Fig. 8e).