For instance, in bone cancer cell lines, deficiency of CDKN2A alone can explain the dependency to TYMS. On the other hand, dependency to TYMS in CDKN2A-mutant pancreatic cancer lines correlates with TYMP expression levels, while in esophageal cancer cell lines both TYMP expression levels and CDKN2A status together can better explain TYMS sensitivity (Fig. 3j, Supplementary Fig. 5 and 6). Here, TYMP is linked to familial pancreatic carcinoma.