ACACA and cancer: For instance, Jerby-Arnon, L. et al. developed an approach (DAISY- data mining synthetic lethality identification pipeline) that led to the discovery of SL partners for the tumor suppressor VHL. Sinha, S. et al. presented MiSL (Mining Synthetic Lethals), an algorithm to identify mutation-specific SL partners in cancers and identified a SL interaction between the isocitrate dehydrogenase 1 (IDH1) mutation and the acetyl-CoA carboxylase 1 (ACACA).