To investigate if the predicted dependency on BRIP1 in the absence of ALDH2 expression represents a potential tumor vulnerability, we divided breast cancer cell lines into two groups: i) defined as the “control group”, comprises SK-BR-3 and MDA-MB-468, which express high levels of ALDH2; ii) defined as the “dependency group”, comprises MCF-7, HCC1954, and HCC1937, which show low levels of ALDH2 (and an inverse pattern of BRIP1 expression). This evidence concerns the gene ALDH2 and neoplasm.