The significance of the CDK4/6-DUB3 axis in regulating breast cancer metastasis has been confirmed by another study [55], demonstrating that the inhibitor of DUB3, WP1130, suppresses DUB3-mediated Snail1 stabilization and that IL-6 stabilizes Snail1 by activating DUB3. This evidence concerns the gene SNAI1 and breast carcinoma.