As research continues, an increasing interest in the function of CRNDE in glioma [14–16] reveals that CRNDE could modulate glioma cell growth and invasion with EGFR activation and through mTOR signaling, and promote malignant progression by attenuating miR-384/PIWIL4/STAT3 axis in GBM. Here, STAT3 is linked to central nervous system cancer.