The central mechanism of hypertension shows that a high-salt diet leads to an increase of the brain’s sodium ion content, which activates the sympathetic nerves through the Na(+)-epithelial sodium channel-renin angiotensin aldosterone system-endogenous digitalis-like factor (Na(+)-ENaC-RAAS-EDLF) axis and promotes the formation of hypertension [37]. Here, REN is linked to hypertensive disorder.