CD44s, in turn, upregulates ZEB1 expression, resulting in a self-enforcing feedback loop with a functional impact on tumorsphere-forming capacity, drug resistance, and tumor recurrence. Research has highlighted the functional role of ZEB1-mediated EMT in MDR, providing a rationale to inhibit ZEB1 which in turn would mitigate EMT features in PC [209]. This evidence concerns the gene ZEB1 and neoplasm.