GLI1 and cancer: Genistein is a natural flavonoid (4,5,7-trihydroxyisoflavone) isolated from soybeans and soy products and has multiple profound anti-cancer effects in various cancers, including breast [320], gastric [321], colon [322], and ovarian cancer [323], primarily through the modulation of Wnt/β-catenin and Hh-Gli1 signaling pathway.