FBXW7 and pachyonychia congenita: Alteration in miRNA expression profiles, such as downregulation of miR-223 and upregulation of its functional downstream target F-box/WD repeat-containing protein 7 (FBW7) [326] as well as upregulation of miR-34a and concomitant downregulation of Notch-1 signaling pathway [327], causing attenuated cell growth and apoptosis, also accounts for the anti-tumor activity of genistein in PC cells.