In pancreatic tumors, Oct4 and Nanog have been found to influence proliferation, colony formation, migration, invasion, chemosensitivity, and tumor formation capacity of PCSCs by controlling the expression of downstream genes TIMP Metallopeptidase Inhibitor 1 (TIMP1), CXCR4, matrix metalloproteinase (MMP)-2, MMP-9, and ABCG2 [146]. This evidence concerns the gene TIMP1 and pancreatic neoplasm.