CD24 shows transient surface localization during PDAC development, and this accounts for a few tumor cells that can be isolated expressing surface CD24 [29]. Further investigations into the clinical relevance of CD24 expression in PC have signified its association with higher tumor stages [21], high grade tumors [21], shorter overall survival (OS) [33], and advanced pT stages [21]. This evidence concerns the gene CD24 and pachyonychia congenita.