As observed in pancreatic tumor xenograft models, siRNA-mediated knockdown of DCLK1 or downregulation by a kinase inhibitor XMD8-92 leads to the decreased expression of angiogenic markers/vascular endothelial growth factor (VEGF) receptors (VEGFR1 and VEGFR2) and EMT-TFs ZEB1, ZEB2, Snail, and Slug [120, 122]. The gene discussed is ZEB1; the disease is pancreatic neoplasm.