NOTCH1 and neoplasm: Functional restoration of miR-34, a bona fide tumor suppressor and downstream target of p53, in human p53-mutant PaCa2 cells resulted in the downregulation of Bcl-2 and Notch-1/2, accompanied by significant inhibition of clonogenic cell growth and invasion, increased apoptosis and cell cycle arrest, and augmented sensitivity to chemotherapy and radiation [269].