Upon interactions with its specific ligand hepatocyte growth factor (HGF), the c-Met signal is relayed downstream to stimulate a series of signaling pathways in tumor cells, such as PI3K/Akt, Janus kinase (JAK)/STAT, Ras/mitogen-​activated protein kinase (MAPK), Src, and Wnt/β-catenin [63, 64], exerting control over tumor proliferation, apoptosis resistance, EMT, angiogenesis, invasion, and metastasis [65–68]. Here, HGF is linked to neoplasm.