SLC39A6 and neoplasm: When the analysis was limited to luminal ER + tumours, high nuclear and high cytoplasmic SLC39A6 protein expression was significantly associated with low tumour grade (P < 0.0001 and P = 0.009), low mitotic count (P = 0.001, only nuclear expression), a low nuclear pleomorphism score (P < 0.0001 and P = 0.005), early tumour stage (P = 0.020, only nuclear expression) and good NPI scores (P < 0.0001 and P = 0.014; Table 1).