Herein, the expression of bax, bcl2, caspase-3 and caspase-8 genes of sw-1736 thyroid cancer cell line was examined after the incubation with 7 μl of the batch curcumin-niosome nanoparticles in 100 μl of cell culture media for 72 h (Fig. 6). Here, CASP8 is linked to thyroid gland carcinoma.