Therefore, GPUIN1 showed an upregulation in BLCA, BRCA, CHOL, ESCA, HNSC, KIRP, LUAD, LUSC, PAAD, STAD, and UCEC, and a downregulation in GBM, indicating that GPRIN1 might play a key role in these 12 kinds of tumorigenesis. Here, GPRIN1 is linked to glioblastoma.