Hyperactivation of S6K has also been observed in adipocyte precursor and osteosarcoma cell lines expressing LMNA mutations associated with Type 2 Familial Partial Lipodystrophy (FPLD2) and Mandibuloacral Dysplasia (MADA), respectively (Evangelisti et al., 2015; Pellegrini et al., 2019). This evidence concerns the gene RPS6KB1 and mandibuloacral dysplasia with type A lipodystrophy.