ZMPSTE24 and Hutchinson-Gilford progeria syndrome: These findings suggest that hyperactivation of mTOR signaling may be an early event in the onset of HGPS pathology in Mtor+/+LMNAG/G mice, but its activity is age‐, phenotype‐, and tissue‐dependent, similar to what has been observed for Zmpste24−/− mice (Pan et al., 2020), and which may be informative to the rational design of a therapeutic approach involving chemical inhibition of mTOR signaling.