Univariate analysis showed that KCTD11, high TNM classification and positive lymph node metastasis were significant prognostic factors for NSCLC (low KCTD11 expression: hazard ratio 0.368, p < 0.01; positive lymph node metastasis: hazard ratio 2.611, p < 0.001; and high TNM classification: hazard ratio 2.172, p = 0.01). This evidence concerns the gene KCTD11 and non-small cell lung carcinoma.