This study reports the mapping of the polyclonal antibody responses in a large number of clinically well‐characterized convalescent COVID‐19 patients with a comprehensive panel of microarrayed folded and unfolded SARS‐CoV‐2 proteins and S‐derived peptides in relation to their virus neutralization activity and ability to inhibit the RBD‐ACE2 interaction. This evidence concerns the gene ACE2 and COVID-19.