The authors did not find a statistically significant difference between the groups in the overall population (adjusted HR 0.78, 95% CI 0.60–1.02), although in patients with Crohn’s disease (HR 0.62, 95% CI 0.44–0.86) and those younger than 45 years (﻿HR 0.55, 95% CI 0.34–0.87) a protective effect of anti-TNF agents reached statistical significance136. The gene discussed is TNF; the disease is Crohn disease.