NFKB1 and cancer: Among the putative KIRA6 off-targets, we then focused our attention on the molecular chaperones HSP60 and HSP90 for different reasons: (i) except for actin, both molecular chaperones were the top-listed ATP-binding proteins identified by MS (Table 1), (ii) HSP90 is a known regulator of NF-κB-driven inflammatory signaling; [31, 33, 34], (iii) the cytosolic fraction of HSP60 has been recently shown to promote CXCL8 production by cancer cells by positively regulating NF-κB [35], and iv) no studies have linked intracellular HSP60 or HSP90 to ICD.