PLOD1 and polycystic ovary syndrome: Additionally, in an infertile DHEA-PCOS model, elevated LH and testosterone with decreased estrogen (Supplementary Fig. 3a-d) led to a disordered estrous cycle lacking the metestrus and diestrus periods (Supplementary Fig. 3e, f), as well as abnormally larger follicles with rare corpora luteum in ovaries (Supplementary Fig. 3g).