TP53 and Miyoshi myopathy: Both signatures were correlated with features of high-risk MM (Fig. 3a), including translocations involving MAF/MAFB (p = 0.0005), APOBEC mutational activity (i.e., mutational signatures; p < 0.0001), biallelic TP53 inactivation (p < 0.0001), and gain/amplification of 1q21 (p < 0.0001; Fig. 3b-e).