GPT and obesity due to melanocortin 4 receptor deficiency: Consistent with increased obesity, insulin resistance and FFAs HFD-fed mice treated with CPF and housed at TN had increased liver weights (Fig. 2i), liver TGs (Fig. 2j, k) and serum ALT (Fig. 2l) and AST (Fig. 2m) indicative of greater NAFLD than HFD controls.