For instance, HDAC inhibitors can increase immunogenicity through several mechanisms such as blocking the effects of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs)25,26; enhancing the expression of cancer antigens silenced by immunoediting27; and/or triggering DNA damage and cell death to activate danger signals and recruit immune cells28,29. The gene discussed is HDAC9; the disease is cancer.