Besides, studies confirmed WNT pathway alterations in CRC including APC splice-site alterations in intronic regions and large in-frame deletions in CTNNB1 [6], alterations in PI3K-Akt signaling pathway and pathways involved in cell adhesion, extracellular matrix (ECM), hepatic stellate activation were found specifically enriched in metastases [8]. Here, APC is linked to colorectal carcinoma.