Moreover, in liver metastases, the top-10 mutations with the highest median CCFs were associated with calcium channel or cell-adhesion functions such as CACNA1H, PCDHA2, PCDHB15, RYR1, FAT4, indicating tumor cell mobility mediated by Ca2+ [18] might play pivotal roles at the early stage of liver metastasis. Here, RYR1 is linked to neoplasm.