For example, Zhang et al. found that CXCL1/CXCR2 signaling could drive the infiltration of monocyte in atria accelerating atrial remodeling and AF after hypertension [42], while these effects could be mitigated by inhibiting CXCR2 with SB225002 (ref [41]). Here, CXCR2 is linked to atrial fibrillation.