Previous studies report that DAAM1 mediates the migration of multiple cancer cells via Rho signaling pathways, including BrCa cells [11], glioblastoma cells [25], melanoma cells [9], ovarian cancer cells [14], esophageal squamous cell carcinoma cells [26], and osteosarcoma cells [27]. This evidence concerns the gene DAAM1 and esophageal squamous cell carcinoma.