KNG1 and breast cancer: Therefore, although two different mechanisms for the inhibition of NMDARs may be present in the basal dendrites of BC-L5PNs, our data strongly suggest that NMDAR–BK modulation of synaptic transmission and long-term synaptic plasticity is a forward regulatory mechanism involving thalamocortical projections to a restricted population of BC-L5PNs in conditions in which the prior activation of postsynaptic NMDARs is mandatory, and action potentials are not required.