We identified novel variants in previously reported ID causing genes i.e. ARX, C5orf42 and METTL4, a recurrent variant in GNE which is involved in causing ID and a CNV in IL1RAPL1. We also report novel missense variants in ELFN1 and CCS to be implicated in intellectual disability which are not reported previously in ID phenotype. The gene discussed is CPLANE1; the disease is Intellectual disability.