IL1RAPL1 and Intellectual disability: We identified novel variants in previously reported ID causing genes i.e. ARX, C5orf42 and METTL4, a recurrent variant in GNE which is involved in causing ID and a CNV in IL1RAPL1. We also report novel missense variants in ELFN1 and CCS to be implicated in intellectual disability which are not reported previously in ID phenotype.