To investigate how circ-GALNT16 mediated the SUMOylation of hnRNPK, we identified SENP2, which was reported to antagonistically mediate the SUMOylation of hnRNPK in HeLa and HCC cells and could interact with hnRNPK in CRC cells [16, 25]. This evidence concerns the gene HNRNPK and colorectal carcinoma.