To investigate how circ-GALNT16 mediated the SUMOylation of hnRNPK, we identified SENP2, which was reported to antagonistically mediate the SUMOylation of hnRNPK in HeLa and HCC cells and could interact with hnRNPK in CRC cells [16, 25]. The gene discussed is GALNT16; the disease is hepatocellular carcinoma.