LDHA and central nervous system cancer: To assess whether cyclin G2 inhibits proliferation, migration, invasion, glycolysis, or promote apoptosis of glioma cells by modulating Y10 phosphorylation of LDHA, we knocked down endogenous LDHA and restored the expression of wild-type LDHA as well as Y10F mutant LDHA either with or without cyclin G2 overexpression in glioma cells.